Another issue I've just noticed post patch. The fatigue levels of the substitutions seem to drain at a substantially faster level than the starting 15. See the below picture (not sure why its so small) . I subbed all of the forwards on between 60-65 minutes, and by the 85th minute they were all in the red, and far below the players I subbed them on for, none of whom were anywhere near being in the red when taken off, and the players who had been on for the full match.
I only noticed this because the number 20, Koteka, had a 5 metre run to score but looked like he was walking when I was holding the sprint button and got caught by a front row, so went to check his stats, which were vastly superior in speed and acceleration to the front row who caught him, and noticed the fatigue drain (although the front row catching him may also be caused by the annoying slowing down of all forwards from the patch).